For instance, in mouse embryonic stem cells, targeted disruption of glucose-6-phosphate dehydrogenase, which is the rate-limiting enzyme in the pentose phosphate pathway, the predominant metabolic pathway for the generation of NADPH (a cofactor of GR), renders cells extremely sensitive to H 2 O 2 -induced cell death 34
Effect of plant growth regulators on callus induction in Solanum torvum SW: a medicinal plant
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Therefore, ferroptosis emerges as a core mechanism that intimately links age, the most universal risk factor, to cognitive decline, the shared pathological outcome