Methylcobalamin is available as an unlicensed supplement but is not a routinely recommended medicinal product in the UK and should not be substituted for licensed preparations without clinical advice
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Berberine also reduces apoptosis by modulating the PI3K/Akt and p38-MAPK pathways ( Moreover, berberine promotes neurogenesis in the dentate gyrus after TBI by increasing the expression of Brain-derived neurotrophic factor (BDNF) (Suwannakot et al., 2022)
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Future directions and clinical translation challengestowards mitochondria-guided precision treatment for CRC With a deeper understanding of mitochondrial metabolic reprogramming in CRC, both research and clinical fields are collectively advancing its translation from basic discoveries to precision therapies
