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The activity of GDH is regulated not just by the availability of substrate (glutamate) and co-enzyme (NADH), but also by a variety of molecules that bind to an additional regulatory site on the enzyme

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doi:10.1038/s41386-023-01614-3

A significant decrease in daily calories intake was observed in the low-carbohydrate group (from 2205 624 kcal to 1667 404 kcal, p = 0.004), whereas no significant change occurred in the high-carbohydrate group

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512,513 Correcting exon 7 splicing in SMN2 can compensate for the lack of SMN1, producing functional SMN protein and improving symptoms