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Differential effects of ATP7A and ATP7B regulating copper metabolism MURR1 domain protein 1 (COMMD1) on the formation of mutant Cu, Zn-SOD1 fibrils (increase) or parkin inclusions (decrease) as well as the Htt aggregates (unaltered), however, suggest mechanistic diversity [286]

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Meanwhile, titanium dioxide NPs have been shown to exhibit long-term ecotoxicity by causing oxidative stress in soil microbes, which can result in a 50% reduction in enzymatic activity [116]

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However, stacking increases complexity and should be clinician-guided