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Notably, total IGF-I and IGFBPs were unchanged over this short-duration window, dissociating the observed bone-growth effect from sustained IGF-1 axis activation in this model

However, these are not ideal to be using long term due to their suppression of stomach acid

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1 Thurston RC, El Khoudary SR, Sutton-Tyrrell K, et al

Side Effects and Safety Considerations The most common side effects across GLP1/GIP/glucagon agonists include: Nausea, vomiting, or reduced appetite that feels too strong. Diarrhea or constipation