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Consistent with the observations in human elderly Leydig cells, H2O2-induced senescent TM3 Leydig cells exhibited a predominant nuclear localization of FOXO4, in contrast to untreated controls where it remained mostly cytoplasmic
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In research models, it's shown impressive regenerative effects: But and this is important most of this data comes from animal studies or anecdotal human use, not large-scale clinical trials
These benefits are valuable as chronic inflammation and oxidative damage have been linked to aging and reduced tissue repair