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Brain-resident CD4 T cells, entering the CNS during birth, affect CNS development, synaptic pruning, anxiety behaviors, and the transcriptional maturation in microglia and innate immune compartments 66

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Inflammation in adipose tissue is significantly associated with the histological severity of MASLD, with inflammatory processes in visceral adipose tissue potentially preceding and contributing to the progression of the disease to MASH and liver fibrosis [44]