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One of the examples is a retrospective study on 12 patients with knee pain who had an intra-articular injection of the peptide into their knees [104]

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To perform virtual screening using pharmacophore model ensembles coupled with YN2, 5 parameters were required: the number of stable and unstable conformations, the minimum ensemble phase score value among known active molecules (, the maximum ensemble phase score value among known active molecules , and the YN2 threshold