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10.1016/j.steroids.2014.05.002 54 JunF.YaminL.XinliX.ZheL.MinZ.BoZ.et al (2012)

Standard protocols often recommend cycling to prevent receptor desensitization, while lower doses may allow for more extended use without the same concerns about diminishing returns

Whether a person is making too much uric acid, or has difficulty excreting it via the kidney, allopurinols decrease in uric acid production leads to the same goal: a decreased total body uric acid