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Probiotics and fructo-oligosaccharide intervention modulate the microbiota-gut brain axis to improve autism spectrum reducing also the hyper-serotonergic state and the dopamine metabolism disorder

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In another double-blind, placebo-controlled trial, an improvement in cognitive performance (i.e., MMSE score) was reported in AD patients randomized to receive 800 IU/day of all - rac --tocopherol (360 mg/day of RRR --tocopherol) for six months only when the treatment effectively reduced oxidative stress (as assessed by the measure of total glutathione and markers of lipid peroxidation in the blood) (110)

[DOI] [PMC free article] [PubMed] [Google Scholar] Zhu C, Huang M, Kim HG, Chowdhury K, Gao J, Liu S, et al

10.3389/fimmu.2017.00093 237 Ron-HarelN.GhergurovichJ

Prolonged metabolic stress impairs mitophagy and reduces mitochondrial function, as indicated by decreased oxidative phosphorylation, impaired ATP synthesis, and elevated reactive oxygen species (ROS) generation (22)