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Conclusion By focusing on the ROS-related PIPN mechanism, both antioxidant drugs (e.g., small molecular drugs, traditional medicines/active ingredients) and tailor-made nanosystems (e.g., tumor-targeting Pt nanosystems and anti-ROS nanosystems) have demonstrated to be effective in the prevention and treatment of PIPN

This method bypasses the digestive system, ensuring that the vitamin is rapidly absorbed and utilized by the body

Compound 3 , ( E )2(3,4dihydroxy5nitrobenzylidene) N phenylhydrazine1carbothioamide, was potent in the order of nM, with an IC 50 value of 0.0437 M, being 734 times more potent than its analog 3,4dihydroxy5nitrobenzaldehyde (DHNB) and 173 times more potent than the drug allopurinol, demonstrating its excellent inhibitory activity (Figure 4)

doi:10.1152/physrev.1999.79.2.511

Metformin inhibits mitochondrial permeability transition and cell death: a pharmacological in vitro study

Krakowiak P, Walker CK, Bremer AA, Baker AS, Ozonoff S, Hansen RL, et al