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Dabei handelt es sich in der Regel eher um eine allmhliche, subtile Vernderung als um eine dramatische Vernderung
Other proteins that bind KEAP1 and interfere with KEAP1-NRF2 interaction, promoting NRF2 accumulation and function in the nucleus, include: phosphoglycerate mutase 5 (PGAM5, a serine/threonine phosphatase related to the phosphoglycerate mutase family), which has been reported to be associated with mitochondria, so its interaction with KEAP1 may be regulated by mitochondrial signalling processes [187, 188]
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Consequently, research is now extending into other omics fields, such as metabolomics, microbiomics, and transcriptomics to uncover additional biomarkers that might better predict individual responses to therapies
This could include assessment of the gut microbiome, testing for relevant disease conditions associated with oxidative stress, and exploring the possibility of a genetic component
