Initially identified as nine fundamental biological drivers of aging (13), the list has been updated to include twelve hallmarks: genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, disabled macroautophagy, deregulated nutrient-sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication, chronic inflammation, and dysbiosis (14)
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Both canonical inhibitors and serpins are important regulators in balancing not just NSP activity, but other serine proteases as well, in both tissues and circulation (92)
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The outcomes of both training and testing the models for the nine families of inhibitors are detailed in Supplementary Tables S816
"By boosting it, you're allowing the skin to do what it's naturally supposed to be doing: stimulating repair mechanisms and supporting its own healing properties," explains Babar
