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Migraines are more severe and complex: usually an intense, throbbing pain on one side of the head alongside other symptoms including nausea and sensitivity to light and sound

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In OA, however, due to an inflammatory microenvironment and cellular stress, glycolytic flux often becomes further elevated to meet energy demands, while mitochondrial dysfunction may reduce oxidative phosphorylation efficiency (100)

Lack of organelles and therefore the mitochondria-associated apoptotic machinery has raised concerns that highly specialized terminally differentiated RBCs can undergo apoptosis