ProtasPTKpkaARybi-SzuminskaAStoronowiczJKlukowskiMWasilewskaA
Recommendation (Evidence Strength: Grade C) Systemic (oral) long-term glucocorticoid administration should not be offered
Proteins are especially susceptible to carbonyl stress 70,71
Left unchecked, oxidative stress leads to inflammation, disease, disfunction, and degeneration of cells, tissues, organs and overall health
epidemiological evidence reveals clear agedependent trends, a slightly higher prevalence in males, and striking geographic disparities, particularly between highincome and resourcelimited regions
If the transfer of one oxygen to a substrate molecule escapes control mechanisms, uncoupling in the ROS formation and subsequent damage to biomolecules may occur