This enhanced photodynamic effect is attributed to the peroxidase- and catalase-like activities of the MOF-919 core, which facilitate the in situ conversion of H 2 O 2 to both O 2 and OH and subsequently promote 1 O 2 generation under laser
While GSH scavenges OH, 1 O2, and NO directly, it catalytically detoxifies hydrogen peroxides (H 2 O 2 ), OONO , and lipid peroxides by activation of glutathione peroxidases
There are oral products and injectable forms, and the route may affect where it acts most
The key lesson from ACE-031 was that broad TGF-beta superfamily inhibition produces unacceptable off-target effects, particularly vascular toxicity
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