During Type 2 immunity, the upregulation of airway epithelial 15-lipoxygenase-1 (15LO1) partners with phosphatidylethanolamine binding protein 1 (PEBP1), forming a complex that shifts substrate specificity toward membrane phospholipids to catalyze pro-ferroptotic 15-HpETE-PE synthesis, a metabolite normally reduced by glutathione peroxidase 4 (GPX4) to its inert alcohol form (10)
Promotes a healthy response to inflammation
Senolytic agents include natural compounds such as quercetin 13 or fisetin 14 , -galactosidase-activated nanoparticles and prodrugs 15,16,17 or compounds that target different vulnerabilities of senescent cells, such as HSP90 inhibitors 18 , cardiac glycosides 19,20 or NMT inhibitors 21
Pair with vitamin C and zinc for enhanced immune defense
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5.5 Kelch-like ECH-associated protein 1 (KEAP1) inhibitors used in IBD treatment Therapeutic approaches targeting the KEAP1-NRF2 pathway primarily utilize KEAP1 inhibitors (259)
