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Methylation problems will cause the liver to run out of methyl groups quicker, and force it to use sugar to try to complete the phase 2 detox process something science calls glucoronidation meaning to glue together with glucose

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4.2.3 Bile acids Bile acids (BAs) metabolism disorders constitute a significant component of metabolic abnormalities in PCOS (62, 63)

In: Squire L, Berg D, Bloom F, du Lac S, Ghosh A, Spitzer N, eds