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The off period is mainly there to address copper-accumulation concern from the GHK-Cu component, which makes up 62.5% of the blend

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Together, these mechanisms mitigate M1 microglial polarization, promote M2 transition, and prevent degeneration of tyrosine hydroxylase (TH)-positive neurons in the nigrostriatal pathway ( Emerging evidence suggests that BL may exert neuroprotective effects in PD by modulating NF-B signaling and inflammasome activity (Li et al., 2020)