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The resulting data were analyzed based on a 1:1 binding model, from which K on and K off values were obtained, and then K d values were calculated

In vitro studies showed that DHEA and DHEA-S accelerated dermal fibroblast migration (Stevenson et al., 2009) and prevented keratinocyte apoptosis via membrane binding sites (Pomari et al., 2015)

In addition, higher drug concentration was also noticeable in the brain areas

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Thus, non-specific leaking of the proteins through the barrier (Pardridge and Mietus, 1980