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Metallothionein, copper and alpha-synuclein in alpha-synucleinopathies

PMC 2845819

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Step 4: Protect Externally

As the primary factors for the reduced anticancer effect 1) the reduced delivery and uptake of the anticancer agent, 2) the need for the conversion of molecular oxygen (O 2 ) into reactive oxygen species (ROS), 3) the preferred therapeutic effect against highly proliferating cells, which is reduced under hypoxic conditions, or 4) adaptation of the cancer cells by promoting cell survival and upregulating certain resistance pathways, has been suggested 1,2,3,4,5

Those with more severe deficiencies might need higher doses to fill up their B12 stores