glutathione and antibiotic interactions Glutathione-responsive PEGylated florfenicol via disulfide linkage enhances antibacterial activity, pharmacokinetics, biosafety Effects of Glutathione on Antibiotic

Bradley RH, Corwyn RF

K.SuleymanZ.SuleymanB.MammadovR.BulutS.AltunerD.et al (2024)

After the plasma membrane carrier-mediated GSH release from the cell, GSH becomes accessible to the active site of - glutamyl transpeptidase, which catalyzes the breakdown of the GSH - glutamyl bond forming two fractions: The -glutamyl fraction and the cysteinyl-glycine by transferring the -glutamyl fraction to an amino acid acceptor, forming -glutamyl-amino acid

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Similar to digestive enzymes however, it is best to avoid taking glutathione at the same time to avoid it being broken down in the stomach before being absorbed in the intestines