Methylcobalamin is also offered as a dietary supplement
In diabetes research, it is used to investigate the pathogenesis of type 2 diabetes and validate potential therapeutic effects
Results, safety, and dosing remain unproven in human populations
Golding points out that unless the enterohepatic circulation is disrupted, holotranscobalamin levels wont significantly decrease until the livers B12 stores are depleted (Golding, 2016)
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These results have not been replicated in human clinical trials, so it is unclear whether these effects translate to human patients