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While behavioral, genetic, and environmental factors are also involved, the inhalation of significant amounts of chemical substances, such as nicotine, cotinine, NO, ROS, peroxynitrite, and free radicals originating from organic molecules is likely responsible for most of the systemic damage resulting from smoking

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A genome-wide CRISPRCas9 knockout screen identifies FSP1 as the warfarin-resistant vitamin K reductase

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