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Phase 2 clinical trial data published in the New England Journal of Medicine (Jastreboff et al., 2023) demonstrated mean body weight reductions of up to approximately 24% over 48 weeks in adults with obesity a notable finding, though long-term durability data and head-to-head comparisons with other treatments are not yet available

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It reduces SAM consumption, preserves its function as a methyl donor for epigenetic regulation, and further optimizes cellular metabolic efficiency

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In addition, Vitamin B12 helps regulate cell metabolism, including DNA synthesis, fatty acid metabolism and amino acid metabolism

How we reviewed this article: Current Version October 03, 2025 Written By John DiBella Fact-checked By Dr