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However, in autoimmune conditions, dysregulation can lead to the immune system mistakenly attacking healthy tissues

Effect of age at the start of iron chelation therapy on gonadal function in beta-thalassemia major

Effects of a nitrate-rich meal on arterial stiffness and blood pressure in healthy volunteers

Additionally, processes involving kappa kinase (IKK-), c-Jun N-terminal kinase (JNK-1), protein kinase C (PKC), and mammalian target of rapamycin (mTOR)-driven serine modification of IRS1 also contribute to insulin resistance, further intensified by free fatty acids, lipotoxicity, oxidative stress, and inflammation (Stergios et al., 2009)