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The dysfunction of glutamatergic neurotransmission results in neuronal excitotoxicity, meaning that glutamate excites cells to their death

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Nasal route is generally lower-risk for such issues but care must still be taken with formulation, preservation, and absorption variability

( A ) Loss of viability in HeLa cells treated with CHP (40 M), in the presence or absence of liproxstatin-1 (Lipr, 20 M), measured with the CellTox Green cytotoxicity assay