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10.1002/ajh.25103 3 BigotK.GondouinP.BenardR.MontagneP.YoualeJ.PiazzaM.et al (2020)

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Membrane-associated gamma-glutamyl transpeptidase (GT) on the surface of astrocytes converts extracellular GSH to the dipeptide CysGly and subsequently to Cys and Gly, which are transported into the neuron, where they serve as precursors for the synthesis of neuronal GSH (Figure 1)

Thus, only about 50% of a rectal dose can be assumed to bypass the liver

partial pressure of carbon dioxide (PCO 2 ) 8.3 mmHg

Open uncontrolled studies reported selected observations, but FDA found insufficient evidence of effectiveness