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Data availability The entire CAMS dataset is freely available to download from the Copernicus Atmosphere Data Store at Full precision data that were not subject to lossy compression before, as used here, are available from the Copernicus Atmosphere Monitoring Service 62 and the European Centre for Medium-Range Weather Forecasts 63

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Chronic GIPR agonism results in pancreatic islet GIPR functional desensitisation

Specifically, p66Shc can generate ROS through the oxidation of cytochrome c by utilizing the reducing equivalents of the mitochondrial ETC, playing a crucial role in carcinogenesis and aging [44]