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Keywords: GHK, TGF-1, pulmonary fibrosis, epithelial-to-mesenchymal transition, Smad, collagen Introduction Idiopathic pulmonary fibrosis (IPF) is a severe respiratory disease characterized by progressive and diffuse pulmonary fibrosis and restrictive ventilation dysfunction that eventually leads to respiratory failure

Cells were fixed with 4% PFA for 30 minutes, permeabilized with 0.1% Triton X-100, and blocked with 5% normal goat or donkey serum

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Despite the absence of a prolonged anorectic effect, Cagrilintide produced a sustained and significant reduction in body weight in WT mice by 3.4 g after 21 days, while no such effect was observed in KO animals