Instead, the selected literature was analyzed and synthesized thematically, with studies grouped according to biological pathways (e.g., monoaminergic modulation, neurotrophic signaling, HPA-axis regulation, neuroinflammation, oxidative stress, and mitochondrial function) and level of evidence (preclinical versus clinical)
doi: 10.1038/cdd.2013.124 313 LadoireSPenault-LlorcaFSenovillaLDalbanCEnotDLocherCet al
However, some people are at greater risk: People who eat a restrictive diet that does not contain enough B12
We are the greatest country in the world, but we have to fight for that
Therefore, Vitamin B12 and Folate supplements are the mainstay treatment of B12 and Folate deficiencies
As the roles of the insulin-GH-IGF-axis in growth and metabolism, often discussed separately, are intimately linked they will be described jointly here