104 Glucagon-like Peptide 1 Like PP, glucagon-like peptide 1 (GLP-1) is a derivative of pre-proglucagon, and there are two circulating forms identified in mammals: the predominant GLP-1 (7-36) amide, and GLP-1 (7-37)
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in aqueous solution up to 200 C
Prion protein is a key determinant of alcohol sensitivity through the modulation of N -methyl-d-aspartate receptor (NMDAR) activity
Low vitamin B12 levels are associated with having increased levels of homocysteine, contributing to higher levels of depression [2,3]
In summary, clarifying the link between the gut-joint axis and ferroptosis in OA would be of great significance not only for better understanding the pathological processes at multi-levels (local joint tissues, the gut environment, and circulation), but also from a unique angle for guiding novel therapies development in OA Deep investigative approach to understand how major gut bacterial metabolites (tryptophan-derived metabolites, TMAO and so on) modulate ferroptosis in OA is very promising to elucidate the central regulatory mechanism acted by the gut-joint axis on ferroptosis in OA
