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In addition, when the proportions of S-OPA1 and L-OPA1, which mediate mitochondrial fusion are out of balance, mitochondrial fusion in osteoblasts is inhibited, and abnormal mitochondria produce large amounts of mtROS, thereby inducing osteoblast apoptosis [265]

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We also confirmed that polymer incorporation in storage media did not affect NAC stability, as preparation in the gel-forming vehicle (12% F127) did not greatly affect NAC and diNAC content when compared with preparation in water with and without EDTA addition (Supplementary Fig