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The 10-day intensive protocol An alternative approach compresses the same total dose into a shorter timeframe

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TDP-43 exhibits rhythmic expression, and its knockdown disrupts circadian behavior, alters the expression of core clock genes including BMAL1, CLOCK, CRY1, and PER2, and weakens cognition and balancing abilities in mice ( TDP-43 knockdown induces aberrant splicing and downregulation of USP13, which in turn leads to increased ubiquitination and degradation of BMAL1

Biochem J 1999

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Stromal component may be absent