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We set up a meeting with the BSH and informed them that the guideline was frightening patients and would probably lead to them developing irreversible nerve damage

Materials and methods Post-mortem brain samples Frozen post-mortem tissues were obtained from the NICHD Brain and Tissue Bank for Developmental Disorders at the University of Maryland, Baltimore, MD, USA, and from the Autism Tissue Program at the Harvard Brain Tissue Resource Center, Belmont, MA, USA

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During the course of the study, there was no change to the therapeutic regime other than the introduction of parenteral cobalamin supplementation

However, long-term activation of an opioid receptor with either chronic use or abuse of opioids leads to highly undesirable and clinically significant side effects

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