NaV1.1 inhibition can reduce visceral hypersensitivity
Bringing bone broth back into the modern diet offers a simple and delicious means of obtaining the nutrition from parts of the animal that traditional cultures prized
Reinstatler L, Qi YP, Williamson RS, Garn JV, Oakley Jr GP
Bouligny IM, Montalban-Bravo G, Sasaki K, Daver N, Jabbour E, Valero YA, DiNardo CD, Ravandi F, Borthakur G, Bose P, Pemmaraju N, Kornblau SM, Kadia TM, Masarova L, Takahashi K, Andreeff M , Bazinet A, Yang H, Kanagal-Shamanna R, Hosing C, Pierce S, Meyer MA, Huang X, Garcia-Manero G
Small, membrane-permeable, textbook orally-absorbable small molecule
Through real-world case studies, we discuss how structure-based strategies used by medicinal chemists have successfully reduced phototoxic risk and positively impacted medicinal chemistry projects