Notably, 8-hydroxy-2-deoxyguanosine (8-OHdG), a marker of oxidative DNA damage, is elevated in liver biopsy specimens of MASLD patients, and 31 P-MRS imaging has demonstrated ATP depletion consistent with mitochondrial dysfunction [101, 102]
6.2 Alkaloids 6.2.1 Berberine Berberine, an isoquinoline alkaloid from Berberis aristata , has been used for decades to treat intestinal parasites and enteropathogenic diarrhea due to its bactericidal activity, its ability to inhibit protozoan growth, and also to inhibit enterotoxin-induced intestinal electrolyte secretion (217219)
Together, they work to reduce systemic inflammation, improve flexibility, and support profound tissue resilience
Thankfully it can be replenished
At the Annual Shareholders' Meeting held on June 3, 2026, shareholders confirmed this co-optation and renewed Mr Vonderscher's term of office as a director
Redox Biol (2017) 11:6139