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The combination of declining estrogen, changing androgen ratios, and the metabolic stress of weight loss creates a perfect storm for follicular disruption

IGF-1 decreases GH levels by growth hormone releasing hormone (GHRH)-dependent feedback mechanisms

The decreased NADPH production results in insufficient reduction of oxidized glutathione disulfide (GSSG) and Prdx2, thus rendering the antioxidant system less effective ( Classes of Mutation and Spectrum of Deficiency G6PD deficiency is a heterogeneous condition with 217 mutations reported as of 2016

Clinical studies show that kojic acid can reduce melanin synthesis by up to 80%, which translates to visible lightening of dark spots and overall skin tone

Raw counts were imported as AnnData 91 objects