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Peer review Peer review information Nature Chemical Biology thanks Melanie McReynolds, Yi Yang and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

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Pregnant or lactating women should consult a healthcare professional before use

This enormous safety margin explains why serious adverse effects remain essentially unreported in the research literature

Posologie adulte Le dosage peut varier en fonction de diffrentes indications mdicales : Pour le traitement initial de la carence en vitamine B12, la dose habituelle est de 1000mcg SC/IM, administre une fois par jour pendant 1 semaine, suivie d'une dose par semaine pendant 1 mois

10.1007/s00109-019-01743-7 181 WangX.TangY.XieN.BaiJ.JiangS.ZhangY.et al (2022)