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In some embodiments, the otic formulation or composition comprises about 19% by weight of the therapeutic agent, or pharmaceutically acceptable prodrug or salt thereof

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For instance, hippocampal ferroptosis and depressive-like behaviors were observed in lipopolysaccharides (LPS)-induced mice, whereas treatment with ferrostatin-1 (Fer-1), a ferroptosis inhibitor, alleviated depressive-like behaviors of chronic unpredictable mild stress model (CUMS)-induced mice (Mao et al., 2024

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