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However, many of these inhibitors, such as RSL3 and ML162, have exhibited suboptimal pharmacological properties in preclinical animal models, while others like BSO and auranofin have not yielded the desired anti-cancer effects in clinical trials, limiting their potential for clinical translation or application

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For instance, selenoproteins S (SELENOS), N (SELENON), M (SELENOM), T (SELENOT), and F (SELENOF, previously known as 15 kDa selenoprotein (Gladyshev et al., 2016) are endoplasmic reticulum-associated proteins, involved in the unfolded protein response (Bar-Nun, 2005

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