A new, federally funded retrospective study led by Johns Hopkins Medicine strongly suggests that semaglutide and other GLP-1 RAs did not statistically change the risk of developing neovascular age-related macular degeneration (NVAMD) a fast-progressing, blinding condition that is caused by uncontrolled, abnormal blood vessel growth in the back of the eye in adults with type 2 diabetes without a prior history of GLP-1 use
This phenomenon is often explained by the Glutathione Depletion-Methylation Cycle Block (GD-MCB) hypothesis , originally proposed to explain how Long COVID can trigger ME/CFS
Vitamin B12 is sometimes added to support nerve health, which is important because people with diabetes have a higher risk of nerve damage
However, given the prevalence of the MTHFR variants in the general population and from which the laboratory reference values for Hcy are determined, any value near the upper limit of normal may be cause for concern
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