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The ubiquitously expressed pyruvate dehydrogenase (PDH) carries pyruvate, via pyruvate dehydrogenation and formation of acetyl Coenzyme A, into the TCA cycle in both neurons and astrocytes, but no new TCA cycle intermediate is generated by the action of this enzyme alone

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Its core function is to promote the formation of new connections between neurons by binding to hepatocyte growth factor (HGF) with high affinity and enhancing the activity of its receptor c-Met

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