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Autism spectrum disorder is one of the first extraintestinal diseases in the research of the brain-gut axis where increased intestinal permeability has been observed (151)

Depression and inflammation: Correlation between changes in inflammatory markers with antidepressant response and long-term prognosis

It has been shown that complement component C1q can form a multimolecular signaling complex with HMGB1, RAGEs, and leukocyte Ig-like receptor (LAIR-1) in lipid rafts and inhibit inflammation by promoting M2-like macrophage polarization [117]

Administration routes and CNS access Reaching the central nervous system is a challenge for any therapeutic molecule

A 5 mg/mL vial requires different measurements than a 2.5 mg/mL vial