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Upon binding to its target receptor on the adipocyte membrane, the fragment initiates a G-protein coupled cascade: Adenylate Cyclase Activation: The peptide binding induces a conformational change that activates adenylate cyclase

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294 To repair the oxidative stress-induced DNA damage, a large amount of NAD + were consumed by elevated PARPs in response to virus infection, i.e., HSV-1, ZIKV and New Sindbis virus (SV)