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Renal impairment does not meaningfully impact the pharmacokinetics of either semaglutide or tirzepatide

These include, for example, the constitutive androstane receptor (recently identified as a therapeutic target for obesity and related metabolic disorders), PPAR, the pregnane X receptor, the aryl hydrocarbon receptor, lipocalin-type prostaglandin D synthase and apolipoprotein D ( 10 , 40 , 46 - 48 )

Acta Pharmacol Sin 26:799805 Zhou SF, Wang LL, Di YM, Xue CC, Duan W, Li CG, Li Y (2008) Substrates and inhibitors of human multidrug resistance associated proteins and the implications in drug development

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