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The point is not to use those doses but to illustrate the wide safety margin

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Folinic acid can enter the brain and normalize the level of folate coenzymes and has been shown to normalize folate concentrations and improve various social interactions in CFD, including mood, behavior, and verbal communication in children with ASD (190, 195, 196)

She had a history of previous treatment with omeprazole and domperidone on multiple occasions, without any adverse event