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Bile acids can trigger mitochondrial ROS generation in hepatocytes that in turn act to mediate the inactivation of PTPs, resulting in the activation of EGFR (90)

Furthermore, interventional studies in DSS-colitis suggest targeting ferroptosis could be therapeutic: -caryophyllene inhibition of macrophage lipid peroxidation and ferroptosis was linked to suppression of inflammation [12], and seliciclib-treated micethat displayed reduced epithelial ferroptosishad less severe DSS-induced colitis [41]

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High-Dose Antioxidant Support Helps protect cells from oxidative stress

Research Base Comparison Both compounds have substantial published research bases: AOD-9604

2G), in agreement with genetic studies in murine models 31