Characteristics and patterns of pediatric chemotherapy-induced peripheral neuropathy: a systematic review
A critical study
These actions improve the chloride ion currents mediated by GABA ( (2) Selectively inhibits voltage-dependent Na + channels, which reduces or stops the release of neurotransmitters and vasoactive peptides, inhibits action potential propagation, and lessens focal discharges ( (3) It minimizes sustained membrane depolarization, raises the threshold for migraines, inhibits the release of CGRP and glutamate from the trigeminal vascular nerve endings, blocks high-voltage activated Ca 2+ channels, and reduces or prevents the release of neurotransmitters and vasoactive peptides ( (4) Reduces glutamate release as well as discharges by antagonistically binding to the AMPA/kainate receptors while having no discernible effect on the N-methyl-D-aspartic acid receptor subtypes ( (5) Reduces the levels of excitatory neurotransmitters and increases the transmission of inhibitory neurotransmitters by inhibiting carbonic anhydrase (CA), especially CA II and CA IV (White, 2005)
Acknowledgements This work was supported by the National Key Research and Development Program of China (2021YFF1000601), the National Natural Science Foundation of China (32172700) and the Joint Funds of the National Natural Science Foundation of China (U20A2052), and the Fundamental Research Funds for the Central Universities (grant number 2662018PY043)
Myth 3: Oral and IV glutathione work equally well Oral supplements break down in the stomach and may not be as effective
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