Increased levels of anti-oxidant proteins were observed in tamoxifen-resistant MCF-7 cells when compared with non-resistant MCF-7 cells through Nrf2/anti-oxidant response element (ARE) activation [108]
Symptoms of glutathione synthetase deficiency may include: Seizures Hampered reaction to speech and physical stimuli Poor coordination Intellectual disability Vulnerability to bacterial infections Low glutathione levels are also associated with a large number of disorders, including some types of cancer and AIDS
Interferon- prevents cytokine-induced neutrophil infiltration and attenuates bloodbrain barrier disruption
Sclerotherapy is typically better for larger leg veins, while laser treatments are ideal for smaller or facial veins
Lipoic acid, a naturally occurring modification of 1,3-propanedithiol, is a cofactor for many enzymes
In the last few years, various GSH modulation-enhanced combinational therapy strategies have been extensively exploited, accompanied by the development of versatile metal-based nanosystems with different structures, functionalities, and treatment performances ( In view of the rapid development of GSH-responsive and -exhausting metal nanomedicines in potentiating cancer therapy, we summarize and outline the recent advancements, mechanisms, prospects, and challenges in this field from different strategies (Scheme 1)
